ABSTRACT
Objective: To compare therapeutic effect of valsartan and enalapril on QT interval dispersion (QTcd) and premature ventricular contraction in patients with hypertension.Methods: A total of 110 patients with essential hypertension were selected from our hospital.According to random number table, they were randomly and equally divided into valsartan group and enalapril group.QTcd and arrhythmia were compared between two groups.Results: Compared with before treatment, there were significant reductions in QT interval, corrected QT interval (QTc) and QTcd in both groups after treatment (P0.05 all);while in enalapril group, occurrence of premature ventricular contraction was significant positively correlated with SBP, DBP and LVMI (r=0.631, 0.599, 0.591, P<0.05 all).No severe adverse reactions occurred in either group.Conclusion: Valsartan can significantly reduce QT interval dispersion, blood pressure and incidence rate of premature ventricular contraction in patients with hypertension.The therapeutic effect is better than that of enalapril, which is worth extending.